A System-on-Chip solution for a low power active capsule endoscope with therapeutic capabilities for clip application in the gastrointestinal tract

This paper addresses the circuit implementation challenges resulting from the integration of a therapeutic clip in a magnetically maneuverable wireless capsule intended for colonoscopy. To deal with the size constraints typical of a capsule endoscope, an Application Specific Integrated Circuit (ASIC) has been designed specifically to habilitate the release of the therapeutic clip. The ASIC is a complete System on Chip (SoC) that incorporates a circuit for the low power release of the clip, thus overcoming the limitations of the power supply system. With a size of 14mm2, the ASIC can be incorporated in practically any capsule endoscope, consuming only an idle-state power of 1.5mW

Optical communications through tissue

In capsule endoscopy, the wireless data transmission technologies currently employed suffer from high path loss, heavily impacting on the capsule power budget. Optical data transmission shows, in principle, scope to overcome this limitation, at least in selected tissues. Bench testing technologies, and Monte Carlo simulations on the impact of light scattering on carrier frequency, will be presented and discussed

Frontiers of robotic endoscopic capsules: a review

Digestive diseases are a major burden for society and healthcare systems, and with an aging population, the importance of their effective management will become critical. Healthcare systems worldwide already struggle to insure quality and affordability of healthcare delivery and this will be a significant challenge in the midterm future. Wireless capsule endoscopy (WCE), introduced in 2000 by Given Imaging Ltd., is an example of disruptive technology and represents an attractive alternative to traditional diagnostic techniques. WCE overcomes conventional endoscopy enabling inspection of the digestive system without discomfort or the need for sedation. Thus, it has the advantage of encouraging patients to undergo gastrointestinal (GI) tract examinations and of facilitating mass screening programmes. With the integration of further capabilities based on microrobotics, e.g. active locomotion and embedded therapeutic modules, WCE could become the key-technology for GI diagnosis and treatment. This review presents a research update on WCE and describes the state-of-the-art of current endoscopic devices with a focus on research-oriented robotic capsule endoscopes enabled by microsystem technologies. The article also presents a visionary perspective on WCE potential for screening, diagnostic and therapeutic endoscopic procedures

A System-on-Chip solution for a low power active capsule endoscope with therapeutic capabilities for clip application in the gastrointestinal tract

This paper addresses the circuit implementation challenges resulting from the integration of a therapeutic clip in a magnetically maneuverable wireless capsule intended for colonoscopy. To deal with the size constraints typical of a capsule endoscope, an Application Specific Integrated Circuit (ASIC) has been designed specifically to habilitate the release of the therapeutic clip. The ASIC is a complete System on Chip (SoC) that incorporates a circuit for the low power release of the clip, thus overcoming the limitations of the power supply system. With a size of 14mm2, the ASIC can be incorporated in practically any capsule endoscope, consuming only an idle-state power of 1.5mW

An innovative robotic platform for magnetically-driven painless colonoscopy

Colorectal cancer (CRC) represents a significant medical threat with a dramatic impact on the healthcare system with around 1.3 million patients worldwide, causing more than 700 thousand deaths annually. A key-aspect to successful and cost-effective disease management is represented by the early detection of CRC at asymptomatic stage. For this reason, population screening is highly recommended for patients older than 50 years or at high risk for familiarity. Currently, the standard endoscopic techniques do not meet this need. In recent years, innovative endoscopic robotic techniques and active locomotion devices have been developed as alternatives to conventional colonoscopy. The magnetically-driven robotic platform, presented by the authors, is conceived to perform less invasive and more comfortable colonoscopy with the aim to promote screening campaigns for detection of early colorectal neoplasm

Physical simulator for colonoscopy: a modular design approach and validation

Simulators for gastrointestinal endoscopy offer the opportunity to train and assess clinicians’ skills in a low-risk and reliable environment. Physical simulators can enable a direct instrument-to-organ interaction not provided by virtual platforms. However, they present scarce visual realism and limited variability of the anatomical conditions. Herein, the authors present an innovative and low-cost methodology for designing and fabricating modular silicone colon simulators. The fabrication pipeline envisages parametric customization and development of 3D-printed molds for silicone pouring to obtain colon segments. The sizing of each colon segment is based on clinical data extracted by CT colonography images. Straight and curved segments are connected through silicone conjuncts to realize a customized and modular monolithic physical simulator. A 130 cm-long colon simulator prototype with assorted magnetically-connected polyps was fabricated and laid on a custom-made sensorized abdominal phantom. Content, face, and construct validity of the designed simulator were assessed by 17 endoscopists. In summary, this work demonstrated promising results for improving accessibility and flexibility of current colonoscopy physical simulators, paving the way for modular and personalized training programs.This work was supported by the ATLAS project. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 813782